Dr. Jeff Goldstein, MD, PhD has received a K08 Clinical Investigator Award from the National Institute of Biomedical Imaging and Biomedical Engineering (NIBIB). This career development award will help Dr. Goldstein develop an independent research program in computational developmental pathology. The research goals of this proposal will focus on applications in placenta, and developing computational tools and data resources for research and diagnosis of placental pathology. The placenta is the locus for most diseases in pregnancy, alternately driving and showing changes from preeclampsia, preterm birth, gestational diabetes, and others. Beyond pregnancy, placental abnormalities have been linked to childhood asthma, cardiovascular disease, and cancer. Yet, robust, quantitative descriptions of the placenta in health and disease are lacking, and many diseases lack well-described anomalies. Computational tools will help standardize interpretation of placental histology, and to identify patterns associated with maternal and child health.